Eudragit
Polyacrylic resin is the cationic or anionic copolymer generated from the polymerization of DMAEMA dimethylaminoethyl methacrylate, methacrylic acid and methacrylic acid ester in different proportions.
Medicinal resin EUDRAGIT®
Chemical description: Polyacrylic resin is the cationic or anionic copolymer generated from the polymerization of DMAEMA dimethylaminoethyl methacrylate, methacrylic acid and methacrylic acid ester in different proportions. (The product meets USP/NF, Eur., Ph., JP pharmacopoeia standards)
Brand:Eudragit®
(Non-PH type)
General name
|
Chemical compostion
|
Solubility
|
Appearance
|
Main application
|
RL 100
DMF# 1242
|
Ethyl acrylate, methyl methacrylate, methyl methacrylate thrimethylamine ethyl ester chloride copolymer (1:2:0.2) |
water insoluble high permeablility
|
Particle
|
Sustained release coating |
RL PO
DMF# 1242
|
Powder
|
RL 30D
DMF# 1242
|
30% aqueous dispersion
|
RS 100
DMF# 1242
|
Ethyl acrylate, methyl methacrylate, methyl methacrylate thrimethylamine ethyl ester chloride copolymer (1:2:0.1) |
Water insoluble low permeability |
Particle
|
Sustained release coating
|
RS PO
DMF# 1242
|
Powder
|
RS 30D
DMF# 1242
|
30% aqueous dispersion
|
NE 30D
DMF# 1242
|
Ethyl acrylate, methyl methacrylate(2:1)copolymer |
Medium permeability
|
30% aqueous dispersion
|
Sustained release coating
|
RD 100
DMF# 1242
|
Eudragit RL and carboxymethycellulose sodium (9:1) compound |
Water insoluble
|
Powder
|
Rapid disintegrating moisture-proof coating
|
(PH type)
Brand
|
Chemical compostion
|
Solubility
|
Appearance
|
Main application
|
E 100
DMF# 1242
|
Butyl methacrylate, dimethylaminoethyl methacrylate and methyl methacrylate copolymer (1:2:1) |
pH<5 dissolve
|
Particle
|
Rapid disintegrating coating material
|
E PO
DMF# 1242
|
Powder
|
L30D-55
DMF# 2584
|
Methacrylic acid, ethyl acrylate (1:1) |
pH>5.5 dissolve |
30% aqueous dispersion
|
Enteric coating
|
L100-55
DMF# 2584
|
Powder
|
L100
DMF# 1242
|
Ethyl acrylate, methyl methacrylate(2:1) copolymer |
pH>6.0 dissolve
|
Powder
|
Enteric coating
|
S 100
DMF# 1242
|
Eudragit RL and carboxymethylcellulose sodium(9:1) compound |
pH>7.0 dissolve
|
Powder
|
Enteric coating
|
Characteristics application:
Eudragit® polyacrylic resin is mainly used as the film-coat material of oral tablet and capsula which is applicable in transdermal casing pyl, and can also act as new-type gel in rectal administration. Direct compression process. Different types of polymer films vary in solubility.
>>RL, RS ,NE 30D are used as water-insoluble film-coating material in sustained release preparation. RL coating is better in permeability compared with RS coating. When compounding these two kinds coating material, you will gain film-coating with different permeability which can be made into wet particles with water and organic solvent to act as retarder. Large amount of dry polymer (5%~20%) can control the active principle's release from the matrix. Polymer with 10%~50% can adapt direct compression process.
>> L 30D-55 is the anionic moisture dispersion equivalent to C type methacrylic acid copolymer described by USP/NF20.
>> L 30D-55 acts as the enteric coating material of solid preparation which is insoluble in gastric juice but dissolves easily when pH value is above 5.5.
|